In Vitro Inhibition of Chick Embryo Lysyl Hydroxylase by Homogentisic Acid
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چکیده
منابع مشابه
A Chick Embryo in-Vitro Model of Knee Morphogenesis
Background: In this feasibility study, a mechanically loaded in-vitro tissue culture model of joint morphogenesis using the isolated lower extremity of the 8 day old chick embryo was developed to assess the effects of mechanical loading on joint morphogenesis. Methods: The developed in-vitro system allows controlled flexion and extension of the chick embryonic knee with a range of motion of ...
متن کاملLysyl hydroxylase
1 1 4 7 jci.org Volume 125 Number 3 March 2015 Introduction Collagen is the most abundant intrinsic matrix scaffolding protein and contributes to tissue tensile strength (1). Various aspects of collagen metabolism, including its expression, deposition, organization, and turnover, are aberrant in epithelial cancer and have been implicated in tumor progression (2). Evidence from multiple types of...
متن کاملInhibition and activation of the oxidation of homogentisic acid.
The biochemical study of homogentisic acid may be said to have begun with the work of Wolkow and Baumann (3), who demonstrated the relation of this compound to the metabolism of tyrosine. The intervening years have seen much effort expended on studies of the pathway of formation of homogentisic acid, but little on its further metabolism beyond the early discovery that it gives rise to ketone bo...
متن کاملMyogenesis in chick embryo somites in vitro.
Evidence from a number of studies (e.g. Holtzer, 1964; Coon & Cahn, 1966; Konigsberg, 1963) has suggested that the differentiation of some types of cells in vitro may be influenced by environmental factors. Culture conditions can permit or prevent the phenotypic expression of characteristics already determined in the cells. The length of time involved in the stabilization of differentiation app...
متن کاملChondrogenesis in chick embryo somites in vitro.
During the embryonic development of vertebral cartilages, cells from the somite mesoderm differentiate into chondrocytes around the spinal cord and notochord. Grafting experiments in amphibian and chick embryos have indicated that the spinal cord and notochord have some influence on this differentiation of somite cells to cartilage (Holtzer & Detwiler, 1953; Watterson, Fowler & Fowler, 1954). F...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1977
ISSN: 0021-9738
DOI: 10.1172/jci108730